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SPHK1 (基因名), Sphingosine kinase 1 (蛋白名), sphk1_human.

产品名称:

SPHK1 Antibody

货号:

P2161Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Acetyltransferase SPHK1, SK 1, SK1, SPHK, SPK

序列号:

Q9NYA1

反应性:

human,mouse,rat

免疫原:

Recombinant human SPHK1 protein ( R2161h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cardiovascular

规格 & 价格:

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Human SPHK1 Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemical staining of paraffin embedded human skeletal muscle tissue using SPHK1 antibody.

通用注释

亚单元:

Interacts with ACY1 (By similarity). Binds to calmodulin. Interacts with SPHKAP (PubMed:12080051). Interacts with CIB1, the interaction occurs in a calcium-dependent manner (PubMed:19854831). Interacts with TRAF2 (PubMed:20577214). Interacts with EEF1A1; the interaction enhances SPHK1 kinase activity (PubMed:18263879).

功能:

Has serine acetyltransferase activity on PTGS2/COX2 in an acetyl-CoA dependent manner. The acetyltransferase activity increases in presence of the kinase substrate, sphingosine. During neuroinflammation, through PTGS2 acetylation, promotes neuronal secretion of specialized preresolving mediators (SPMs), especially 15-R-lipoxin A4, which results in an increase of phagocytic microglia.

亚细胞位置:

Cytoplasm Nucleus Cell membrane Endosome membrane Peripheral membrane protein Membrane Clathrin-coated pit Cell junction Synapse Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner (PubMed:19854831). Binds to membranes containing negatively charged lipids but not neutral lipids (PubMed:24929359). Recruited to endocytic membranes by sphingosine where promotes membrane fusion (By similarity).

数据库链接

UniGene:

Hs.68061

SMR:

Q9NYA1

STRING:

9606.ENSP00000313681

KEGG:

hsa:8877

MIM:

603730

Pfam: