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SSTR2 (基因名), Somatostatin receptor type 2 (蛋白名), ssr2_human.

产品名称:

SSTR2 Antibody

货号:

P2292Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

SRIF-1, SS-2-R

序列号:

P30874

反应性:

human

免疫原:

Recombinant human SSTR2 protein ( R2292h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

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Human SSTR2 Polyclonal Antibody

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产品说明书

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R&D 技术数据

Immunohistochemical staining of SSTR2 in human pancreatic islands using SSTR2 antibody.

通用注释

亚单元:

Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).

功能:

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

亚细胞位置:

Cell membrane Multi-pass membrane protein Cytoplasm Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.

数据库链接

UniGene:

Hs.514451

SMR:

P30874

STRING:

9606.ENSP00000350198

KEGG:

hsa:6752

MIM:

182452

Pfam: