首页 > 重组蛋白 > Human DDR1 Recombinant Protein

DDR1 (基因名), Epithelial discoidin domain-containing receptor 1 (蛋白名), ddr1_human.

产品名称:

Human DDR1/ Epithelial discoidin domain-containing receptor 1 Recombinant Protein
上皮细胞盘状结构域受体1

货号:

R15103h

商标:

EIAab^®

监管等级:

RUO

别名:

CD167 antigen-like family member A, Tyrosine-protein kinase CAK, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, Tyrosine kinase DDR, MCK-10, CD167a, Epithelial discoidin domain receptor 1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE

序列号:

Q08345

来源:

E.coli

种属:

Human

标签:

His

序列:

Recombinant protein

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human DDR1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 6p21.33 by HGNC 6p21.33 by Entrez Gene 6p21.33 by Ensembl

DDR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2.

功能:

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

亚细胞位置:

Isoform 4 Cell membrane Single-pass type I membrane protein

数据库链接

UniGene:

Hs.631988

SMR:

Q08345

STRING:

9606.ENSP00000365759

KEGG:

hsa:780

MIM:

600408

Pfam:

PF00754

Uniprot:

Q08345

相关产品

序列长度:

913

序列:

仅供参考，详细请咨询（services@eiaab.com）

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913:

LHRFLAEDAL | NTV

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Linkage and association study of discoidin domain receptor 1 as a novel susceptibility gene for childhood IgA nephropathy."

(PMID: 20372823)

[2].

"DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation."

(PMID: 20432435)

[3].

"The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA."

(PMID: 19401332)

[4].

"KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling."

(PMID: 18190796)

[5].

"The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia."

(PMID: 17440435)

[6].

"Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis."

(PMID: 15213330)

[7].

"The genomic structure of discoidin receptor tyrosine kinase."

(PMID: 8796349)

[8].

"Receptor protein tyrosine kinase DDR is up-regulated by p53 protein."

(PMID: 8977099)

[9].

"Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1)."

(PMID: 24509848)

[10].

"Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors."

(PMID: 24768818)

[1].

人上皮细胞盘状结构域受体1(DDR1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人上皮细胞盘状结构域受体1(DDR1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人上皮细胞盘状结构域受体1(DDR1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人上皮细胞盘状结构域受体1(DDR1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人上皮细胞盘状结构域受体1(DDR1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人上皮细胞盘状结构域受体1(DDR1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人上皮细胞盘状结构域受体1(DDR1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人上皮细胞盘状结构域受体1(DDR1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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Human DDR1/ Epithelial discoidin domain-containing receptor 1 Recombinant Protein上皮细胞盘状结构域受体1

R15103h

Human DDR1/ Epithelial discoidin domain-containing receptor 1 Recombinant Protein
上皮细胞盘状结构域受体1