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Hcar2 (基因名), Hydroxycarboxylic acid receptor 2 (蛋白名), hcar2_rat.
产品名称:

Rat Hcar2/ Hydroxycarboxylic acid receptor 2 Recombinant Protein

货号:

R16030r

商标:
EIAab®
监管等级:
别名:

G-protein coupled receptor 109, G-protein coupled receptor 109A, G-protein coupled receptor HM74, Niacin receptor 1, Nicotinic acid receptor, Protein PUMA-G, Gpr109, Gpr109a, Gpr109b, Niacr1, Pumag

序列号:
Q80Z39
来源:
E.coli
种属:
Rat
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Rat Hcar2 Protein
规格 & 价格: cart
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Rat Hcar2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
N/A


功能:
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.


亚细胞位置:
Cell membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。
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