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IFNAR1 (基因名), Interferon alpha/beta receptor 1 (蛋白名), inar1_pig.
产品名称:

Pig IFNAR1/ Interferon alpha/beta receptor 1 Recombinant Protein
干扰素α/β受体1

货号:

R1425p

商标:
EIAab®
监管等级:
别名:

Type I interferon receptor 1, IFN-R-1

序列号:
Q764M8
来源:
E.coli
种属:
Pig
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Pig IFNAR1 Protein
规格 & 价格: cart
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Pig IFNAR1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Heterodimer with IFNAR2. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-467. Interacts with TYK2. Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Interacts with SHMT2; this promotes interaction with FAM175B and the BRISC complex.


功能:
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Late endosome Lysosome Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.


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