首页 > 重组蛋白 > Human MAGED1 Recombinant Protein

MAGED1 (基因名), Melanoma-associated antigen D1 (蛋白名), magd1_human.

产品名称:

Human MAGED1/ Melanoma-associated antigen D1 Recombinant Protein
与黑素瘤相关抗原D1

货号:

R6073h

商标:

EIAab^®

监管等级:

RUO

别名:

MAGE tumor antigen CCF, MAGE-D1 antigen, Neurotrophin receptor-interacting MAGE homolog, PP2250, PRO2292, NRAGE

序列号:

Q9Y5V3

来源:

E.coli

种属:

Human

标签:

His

序列:

1-333aa

预估分子量:

36.63 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human MAGED1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

Recombinant human MAGED1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: Xp11.22 by HGNC Xp11.22 by Entrez Gene Xp11.22 by Ensembl

MAGED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA.

功能:

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.

亚细胞位置:

Cytoplasm Cell membrane Peripheral membrane protein Nucleus Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.

数据库链接

UniGene:

Hs.5258

SMR:

Q9Y5V3

STRING:

9606.ENSP00000364847

KEGG:

hsa:9500

MIM:

300224

Pfam:

PF01454

Uniprot:

Q9Y5V3

相关产品

Mouse Maged1 ELISA Kit

Rat Maged1 ELISA Kit

Pig MAGED1 ELISA Kit

Mouse Maged1 CLIA Kit

Rat Maged1 CLIA Kit

序列长度:

778

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

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778:

AGPIIGPGGT | ASANFAANFG | AIGFFWVE

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation."

(PMID: 15094062)

[2].

"[A new melanoma antigen-encoding gene subfamily in human chromosome X]."

(PMID: 11280991)

[3].

"NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis."

(PMID: 10985348)

[4].

"Identification of a new, unorthodox member of the MAGE gene family."

(PMID: 10409427)

[5].

"MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."

(PMID: 20864041)

[6].

"A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway."

(PMID: 20100315)

[7].

"MAGE-D1 inhibits proliferation, migration and invasion of human breast cancer cells."

(PMID: 19639218)

[8].

"Melanoma-associated antigen family protein-D1 regulation of tumor cell migration, adhesion to endothelium, and actin structures reorganization in response to hypoxic stress."

(PMID: 17453828)

[9].

"NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death."

(PMID: 17488777)

[10].

"The DNA sequence of the human X chromosome."

(PMID: 15772651)

[1].

人与黑素瘤相关抗原D1(MAGED1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人与黑素瘤相关抗原D1(MAGED1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人与黑素瘤相关抗原D1(MAGED1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人与黑素瘤相关抗原D1(MAGED1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人与黑素瘤相关抗原D1(MAGED1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人与黑素瘤相关抗原D1(MAGED1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人与黑素瘤相关抗原D1(MAGED1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人与黑素瘤相关抗原D1(MAGED1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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