首页 > 重组蛋白 > Human MLANA Recombinant Protein

MLANA (基因名), Melanoma antigen recognized by T-cells 1 (蛋白名), mar1_human.

产品名称:

Human MLANA/ Melanoma antigen recognized by T-cells 1 Recombinant Protein
黑色素瘤抗原T细胞1

货号:

R1097h

商标:

EIAab^®

监管等级:

RUO

别名:

Antigen LB39-AA, Antigen SK29-AA, Protein Melan-A, MART-1, MART1

序列号:

Q16655

来源:

E.coli

种属:

Human

标签:

His

序列:

52-118aa

预估分子量:

7.37 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human MLANA Protein

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产品说明书

说明书:

MSDS:

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数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

The PCR product of human MLANA gene was determined by 1% Agarose stained with EB.

Recombinant human MLANA protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 9p24.1 by HGNC 9p24.1 by Entrez Gene 9p24.1 by Ensembl

MLANA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with PMEL. Interacts with GPR143.

功能:

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

亚细胞位置:

Endoplasmic reticulum membrane Single-pass type III membrane protein Golgi apparatus Golgi apparatus Trans-Golgi network membrane Melanosome Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

数据库链接

UniGene:

Hs.154069

SMR:

Q16655

STRING:

9606.ENSP00000370880

KEGG:

hsa:2315

MIM:

605513

Pfam:

PF14991

Uniprot:

Q16655

相关产品

Human MLANA ELISA Kit

Human MLANA CLIA Kit

Human MLANA Polyclonal Antibody

Human MLANA Monoclonal Antibody

Human MLANA

序列长度:

118

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

119:

APPAYEKLSA | EQSPPPYSP

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins."

(PMID: 12191019)

[2].

"Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci."

(PMID: 22190364)

[3].

"Structural basis for the presentation of tumor-associated MHC class II-restricted phosphopeptides to CD4+ T cells."

(PMID: 20417641)

[4].

"Pigmentation-related genes and their implication in malignant melanoma susceptibility."

(PMID: 19320733)

[5].

"The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition."

(PMID: 19717472)

[6].

"Comparison of immunohistochemical markers in the differential diagnosis of adrenocortical tumors: immunohistochemical analysis of adrenocortical tumors."

(PMID: 18091323)

[7].

"Differential expression of melanocytic markers in myoid, lipomatous, and vascular components of renal angiomyolipomas."

(PMID: 17227112)

[8].

"MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes."

(PMID: 15695812)

[9].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

(PMID: 15489334)

[10].

"Expression of Melan-A/MART-1 in primary melanoma cell cultures has prognostic implication in metastatic melanoma patients."

(PMID: 15305155)

[1].

人黑色素瘤抗原T细胞1(MLANA)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人黑色素瘤抗原T细胞1(MLANA)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人黑色素瘤抗原T细胞1(MLANA)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人黑色素瘤抗原T细胞1(MLANA)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人黑色素瘤抗原T细胞1(MLANA)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人黑色素瘤抗原T细胞1(MLANA)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人黑色素瘤抗原T细胞1(MLANA)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人黑色素瘤抗原T细胞1(MLANA)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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