首页 > 重组蛋白 > Human SOCS3 Recombinant Protein

SOCS3 (基因名), Suppressor of cytokine signaling 3 (蛋白名), socs3_human.

产品名称:

Human SOCS3/ Suppressor of cytokine signaling 3 Recombinant Protein
细胞因子信号转导抑制因子3

货号:

R1684h

商标:

EIAab^®

监管等级:

RUO

别名:

Cytokine-inducible SH2 protein 3, STAT-induced STAT inhibitor 3, CIS-3, SSI-3, SOCS-3, CIS3, SSI3

序列号:

O14543

来源:

E.coli

种属:

Human

标签:

His

序列:

46-142aa

预估分子量:

10.67 kDa (monomer)

纯度:

Greater than 92% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Immunology

规格 & 价格:

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 17q25.3 by HGNC 17q25.3 by Entrez Gene 17q25.3 by Ensembl

SOCS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain (PubMed:10421843). Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors (PubMed:12027890, PubMed:14559241). Interaction with CSNK1E stabilizes SOCS3 protein (PubMed:15070676). Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3 (PubMed:15601820). Interacts with CUL5, RNF7, ELOB and ELOC (PubMed:15601820). Interacts with CUL2 (PubMed:15601820). Interacts with FGFR3 (PubMed:16410555). Interacts with INSR (By similarity). Interacts with BCL10; this interaction may interfere with BCL10-binding with PELI2 (By similarity). Interacts with NOD2 (via CARD domain); the interaction promotes NOD2 degradation (PubMed:23019338).

功能:

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.

亚细胞位置:

N/A

数据库链接

UniGene:

Hs.527973

STRING:

9606.ENSP00000330341

KEGG:

hsa:9021

MIM:

604176

Pfam:

PF00017

Uniprot:

O14543

相关产品

Mouse Socs3 ELISA Kit

Rat Socs3 ELISA Kit

Bovine SOCS3 ELISA Kit

Chicken SOCS3 ELISA Kit

Dog SOCS3 ELISA Kit

序列长度:

225

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

225:

LDSYEKVTQL | PGPIREFLDQ | YDAPL

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study."

(PMID: 19083014)

[2].

"Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins."

(PMID: 16402267)

[3].

"A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor."

(PMID: 12027890)

[4].

"Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor."

(PMID: 11071852)

[5].

"Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain."

(PMID: 10421843)

[6].

"Cloning and characterization of novel CIS family genes."

(PMID: 9344848)

[7].

"Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3."

(PMID: 9266833)

[8].

"Polymorphisms in innate immunity genes and risk of childhood leukemia."

(PMID: 20438785)

[9].

"Risk of meningioma and common variation in genes related to innate immunity."

(PMID: 20406964)

[10].

"Association study of 182 candidate genes in anorexia nervosa."

(PMID: 20468064)

[1].

人细胞因子信号转导抑制因子3(SOCS3)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人细胞因子信号转导抑制因子3(SOCS3)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人细胞因子信号转导抑制因子3(SOCS3)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人细胞因子信号转导抑制因子3(SOCS3)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人细胞因子信号转导抑制因子3(SOCS3)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人细胞因子信号转导抑制因子3(SOCS3)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人细胞因子信号转导抑制因子3(SOCS3)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人细胞因子信号转导抑制因子3(SOCS3)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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