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Uba1 (基因名), Ubiquitin-like modifier-activating enzyme 1 (蛋白名), uba1_mouse.
产品名称:

Mouse Uba1/ Ubiquitin-like modifier-activating enzyme 1 Recombinant Protein
类泛素修饰剂激活酶

货号:

R12404m

商标:
EIAab®
监管等级:
别名:

Ubiquitin-activating enzyme E1, Ubiquitin-activating enzyme E1 X, Ubiquitin-like modifier-activating enzyme 1 X, Sbx, Ube1, Ube1ax, Ube1x

序列号:
Q02053
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Mouse Uba1 Protein
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Mouse Uba1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Monomer. Interacts with GAN (via BTB domain).


功能:
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1511901). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.


亚细胞位置:
Cytoplasm Mitochondrion Nucleus


该产品尚未在任何出版物中被引用。
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