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WIPI2 (基因名), WD repeat domain phosphoinositide-interacting protein 2 (蛋白名), wipi2_human.
产品名称:

Human WIPI2/ WD repeat domain phosphoinositide-interacting protein 2 Recombinant Protein

货号:

R15998h

商标:
EIAab®
监管等级:
别名:

WIPI49-like protein 2, CGI-50, WIPI-2

序列号:
Q9Y4P8
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human WIPI2 Protein
规格 & 价格: cart
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Human WIPI2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 7p22.1 by HGNC 7p22.1 by Entrez Gene 7p22.1 by Ensembl
WIPI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with TECPR1, ATG16L1 and ATG5.


功能:
Isoform 4: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.


亚细胞位置:
Preautophagosomal structure membrane Peripheral membrane protein Cytoplasmic side Localizes to omegasomes membranes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P.


该产品尚未在任何出版物中被引用。

[1].
"WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy."

[2].
"WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy."

[3].
"WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1."

[4].
"Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy."

[5].
"Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes."

[6].
"A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens."

[7].
"Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation."

[8].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[9].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[10].
"The DNA sequence of human chromosome 7."
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