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ARHGEF1 (基因名), Rho guanine nucleotide exchange factor 1 (蛋白名), arhg1_human.
产品名称:

Human ARHGEF1/ Rho guanine nucleotide exchange factor 1 Recombinant Protein
鸟嘌呤核苷酸交换因子1

货号:

R1577h

商标:
EIAab®
监管等级:
别名:

115 kDa guanine nucleotide exchange factor, Sub1.5, p115-RhoGEF

序列号:
Q92888
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Epigenetics
Human ARHGEF1 Protein
规格 & 价格: cart
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Human ARHGEF1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19q13.2 by HGNC 19q13.2 by Entrez Gene 19q13.2 by Ensembl
ARHGEF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1 (By similarity). Interacts with CTNNAL1.


功能:
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.


亚细胞位置:
Cytoplasm Membrane Translocated to the membrane by activated GNA13 or LPA stimulation.


该产品尚未在任何出版物中被引用。

[1].
"Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues."

[2].
"Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement."

[3].
"Structure of the rgRGS domain of p115RhoGEF."

[4].
"p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13."

[5].
"Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13."

[6].
"Identification of a novel guanine nucleotide exchange factor for the Rho GTPase."

[7].
"Mutation of ARHGAP9 in patients with coronary spastic angina."

[8].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[9].
"Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho."

[10].
"Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF."
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