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BMP2 (基因名), Bone morphogenetic protein 2 (蛋白名), bmp2_human.
产品名称:

Human BMP2/ Bone morphogenetic protein 2 Recombinant Protein
骨成型蛋白2

货号:

R0013h

商标:
EIAab®
监管等级:
别名:

Bone morphogenetic protein 2A, BMP-2A, BMP-2, BMP2A

序列号:
P12643
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human BMP2 Protein
规格 & 价格: cart
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Human BMP2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 20p12.3 by HGNC 20p12.3 by Entrez Gene 20p12.3 by Ensembl
BMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer; disulfide-linked (PubMed:10074410). Interacts with SOSTDC1 (PubMed:15020244). Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity). Interacts with MAFP5 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).


功能:
Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).


亚细胞位置:
Secreted


该产品尚未在任何出版物中被引用。

[1].
"Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells."

[2].
"L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms."

[3].
"A conserved post-transcriptional BMP2 switch in lung cells."

[4].
"The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature."

[5].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[6].
"Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia."

[7].
"Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate."

[8].
"An approach based on a genome-wide association study reveals candidate loci for narcolepsy."

[9].
"A large-scale candidate gene association study of age at menarche and age at natural menopause."

[10].
"Analyses of shared genetic factors between asthma and obesity in children."
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