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ORAI1 (基因名), Calcium release-activated calcium channel protein 1 (蛋白名), crcm1_human.

产品名称:

Human ORAI1/ Calcium release-activated calcium channel protein 1 CLIA Kit
钙释放激活钙通道蛋白

货号:

U15347h

商标:

EIAab^®

监管等级:

RUO

别名:

Protein orai-1, Transmembrane protein 142A, CRACM1, TMEM142A

检测方法:

CLIA

特异性:

Natural and recombinant human Calcium release-activated calcium channel protein 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cardiovascular

规格 & 价格:

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通用注释

亚单元:

Interacts with STIM1 and STIM2; this regulates channel activity (PubMed:17905723, PubMed:19249086, PubMed:24351972). Interacts with CALM; this may displace STIM1 and STIM2 and might thereby modulate channel activity (PubMed:23109337). Interacts with CRACR2A/EFCAB4B; the interaction is direct and takes place in absence of Ca(2+) (PubMed:20418871). Forms a complex with CRACR2A/EFCAB4B and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with ASPH (isoform 8) (PubMed:22586105). Interacts with SLC35G1 (PubMed:22084111). Interacts with UBQLN1 (PubMed:23307288).

功能:

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).

亚细胞位置:

Cell membrane Multi-pass membrane protein Isoform beta is more mobile in the plasma membrane.

数据库链接

UniGene:

Hs.55148

SMR:

Q96D31

STRING:

9606.ENSP00000328216

KEGG:

hsa:84876

MIM: