Orai1 (基因名), Calcium release-activated calcium channel protein 1 (蛋白名), crcm1_mouse.
产品名称:
Mouse Orai1/ Calcium release-activated calcium channel protein 1 CLIA Kit
钙释放激活钙通道蛋白
货号:
U15347m
商标:
EIAab®
监管等级:
别名:
Protein orai-1, Transmembrane protein 142A, Cracm1, Tmem142a
检测方法:
CLIA
特异性:
Natural and recombinant mouse Calcium release-activated calcium channel protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cardiovascular
通用注释
亚单元:
Interacts with STIM1 and STIM2; this regulates channel activity. Interacts with CALM; this may displace STIM1 and STIM2 and might thereby modulate channel activity. Interacts with CRACR2A/EFCAB4B; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with CRACR2A/EFCAB4B and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with SLC35G1. Interacts with UBQLN1.
功能:
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cytoplasmic vesicle
Autophagosome
Colocalizes with UBQLN1 in the autophagosome.
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