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FBXO45 (基因名), F-box/SPRY domain-containing protein 1 (蛋白名), fbsp1_human.
产品名称:

Human FBXO45/ F-box/SPRY domain-containing protein 1 Recombinant Protein
含F-box/SPRY结构域蛋白

货号:

R3813h

商标:
EIAab®
监管等级:
别名:

F-box only protein 45, hFbxo45, FBX45

序列号:
P0C2W1
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human FBXO45 Protein
规格 & 价格: cart
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Human FBXO45 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 3q29 by HGNC 3q29 by Entrez Gene 3q29 by Ensembl
FBXO45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Forms a complex with MYCBP2 and SKP1 but does not appear to form an authentic SCF (SKP1-CUL1-F-box protein) complex (By similarity). Interacts (via B30.2/SPRY domain) with TP73 (via SAM domain); leading to TP73 ubiquitination and degradation by proteasome. Interacts (via SRY domain) with UNC13A; leading to degradation of UNC13A by the proteasome.


功能:
Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation.


亚细胞位置:
Cell junction Synapse Postsynaptic cell membrane Cell junction Synapse Presynaptic cell membrane


该产品尚未在任何出版物中被引用。

[1].
"The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73."

[2].
"Characterization of estrogen-induced F-box protein FBXO45."

[3].
"Systematic analysis and nomenclature of mammalian F-box proteins."

[4].
"Low Expression of FBXO45 Is Associated with Gastric Cancer Progression and Poor Prognosis."

[5].
"Architecture of the human interactome defines protein communities and disease networks."

[6].
"A Naturally Generated Decoy of the Prostate Apoptosis Response-4 Protein Overcomes Therapy Resistance in Tumors."

[7].
"Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases."

[8].
"The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety."

[9].
"Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways."

[10].
"An organelle-specific protein landscape identifies novel diseases and molecular mechanisms."
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