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OAS2 (基因名), 2'-5'-oligoadenylate synthase 2 (蛋白名), oas2_human.
产品名称:

Human OAS2/ 2'-5'-oligoadenylate synthase 2 Recombinant Protein
2,5-寡腺苷酸合成酶2

货号:

R0722h

商标:
EIAab®
监管等级:
别名:

p69 OAS / p71 OAS, p69OAS / p71OAS, (2-5')oligo(A) synthase 2

序列号:
P29728
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human OAS2 Protein
规格 & 价格: cart
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Human OAS2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 12q24.13 by HGNC 12q24.13 by Entrez Gene 12q24.13 by Ensembl
OAS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer.


功能:
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.


亚细胞位置:
Cytoplasm Cytoplasm Perinuclear region Mitochondrion Nucleus Microsome Endoplasmic reticulum Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.


该产品尚未在任何出版物中被引用。

[1].
"Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection."

[2].
"Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?"

[3].
"The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities."

[4].
"Dengue hemorrhagic fever is associated with polymorphisms in JAK1."

[5].
"Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease."

[6].
"A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients."

[7].
"The finished DNA sequence of human chromosome 12."

[8].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[9].
"Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study."

[10].
"Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions."
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