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ZEB1 (基因名), Zinc finger E-box-binding homeobox 1 (蛋白名), zeb1_human.
产品名称:

Human ZEB1/ Zinc finger E-box-binding homeobox 1 Recombinant Protein
ZEB1

货号:

R14970h

商标:
EIAab®
监管等级:
别名:

NIL-2-A zinc finger protein, Negative regulator of IL2, Transcription factor 8, TCF-8, AREB6, TCF8

序列号:
P37275
来源:
E.coli
种属:
Human
标签:
His
序列:
1-160aa
预估分子量:
17.6 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human ZEB1 Protein
规格 & 价格: cart
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Human ZEB1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human ZEB1 Protein
Recombinant human ZEB1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 10p11.22 by HGNC 10p11.22 by Entrez Gene 10p11.22 by Ensembl
ZEB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts (via N-terminus) with SMARCA4/BRG1.


功能:
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells."

[2].
"Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p."

[3].
"Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy."

[4].
"Posterior polymorphous corneal dystrophy is associated with TCF8 gene mutations and abdominal hernia."

[5].
"The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2."
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